-How amazing it is that astronauts are exploring outer space!
-It’s a challenge, I guess,  ______  man against nature. 
A．ofB．forC．byD．a(chǎn)bout
A
考查介詞。應答句中的I guess是插入語，因此所填介詞與challenge連用，表所屬，用of，選A。
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