Scientists across the world agree that this is an invention of _______ great significance, _______ invention that will greatly change human life.   
A．a(chǎn); theB．a(chǎn); anC．/ ; theD．/ ; an
D
考查冠詞。Of  great significance,固定短語，意義重大的，介詞后一般不加冠詞。結(jié)合上文an invention一項發(fā)明，本句和前文為并列表語，泛指任何一項發(fā)明，故用不定冠詞，詞首音素為元音，故選D。
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