My sister is determined. ________ she has made up her mind, nothing can change it.

A．ThoughB．OnceC．UnlessD．Until

B

解析試題分析：“一旦”下定決心，什么也不能改變（她的決心）。once: as soon as, when, 引導(dǎo)時(shí)間狀語。A項(xiàng)引導(dǎo)讓步狀語從句；C項(xiàng)引導(dǎo)條件狀語從句；D項(xiàng)引導(dǎo)時(shí)間狀語從句，但是要求主句動(dòng)詞為延續(xù)性動(dòng)詞或動(dòng)詞的否定形式。故B項(xiàng)正確。
考點(diǎn)：狀語從句。

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