No one knows how large          universe is， but          man has never given up the  attempt to explore new stars and new planets.
A. the；/           B/; the               C/：/             D the； the
A
考查冠詞的用法。a/an表示泛指，“一個(gè)”；the表示特指，“那個(gè)”。universe“宇宙”，不可數(shù)名詞，且是獨(dú)一無(wú)二的事物，一個(gè)用the修飾；man“人類(lèi)”，前不加冠詞。故選A。
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