He tried his best to solve the problem, _______ difficult it was.

A．whatever B．however C．whichever D．wherever 

B

解析試題分析：No matter +特殊疑問(wèn)詞引導(dǎo)讓步狀語(yǔ)從句，意為：無(wú)論…；意為后面接形容詞difficult，所以使用how.而不是what. 句意：無(wú)論問(wèn)題有多難，他都全力以赴地解決它。故B正確。
考點(diǎn)：考查讓步狀語(yǔ)從句

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