He tried his best to solve the problem,________ difficult it was.
A．howeverB．no matter
C．whateverD．a(chǎn)lthough
A?
however+adj./adv.引導讓步狀語從句，意為“無論多么”。no matter不能單獨使用，后須加what/how/when/where等連詞。C、D兩項后不能接形容詞，故答案為A。
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