____is well-known to all, the great changes have taken place in China.
A．ItB．thatC．AsD．Which
C
考查定語(yǔ)從句。此處有逗號(hào)隔開，此句子不是形式主語(yǔ)的句式，前面的句子修飾后面的句子構(gòu)成一個(gè)非限制性定語(yǔ)從句，as可以放于句首，意思“這一點(diǎn)”來(lái)指代后句。
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